Sodium Channel Inactivation: Molecular Determinants and Modulation
نویسندگان
چکیده
منابع مشابه
Sodium channel inactivation: molecular determinants and modulation.
Voltage-gated sodium channels open (activate) when the membrane is depolarized and close on repolarization (deactivate) but also on continuing depolarization by a process termed inactivation, which leaves the channel refractory, i.e., unable to open again for a period of time. In the "classical" fast inactivation, this time is of the millisecond range, but it can last much longer (up to seconds...
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The intracellular linker L(III-IV) of voltage-gated sodium channels is known to be involved in their mechanism of inactivation. Its primary sequence is well conserved in sodium channels from different tissues and species. However, the role of charged residues in this region, first thought to play an important role in inactivation, has not been well identified, whereas the IFM triad (I1488-M1490...
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A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2005
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00024.2004